Schematic model of the regulation of auxin and cytokinin during early rhizobia infection event. Plant auxin is transported towards the root tip, also transported in acropetal direction (from root tip to elongation zone). After rhizobia infection, acropetal auxin transport at the inner cortical, endodermal and/or pericycle. The reduction of acropetal auxin transport increases auxin concentration at the rhizobia infection site, the location of a future nodule primordium, to promote nodule development. After rhizobia infection, cytokinin biosynthesis is up-regulated and perceived at the inner cortex. The increased level of cytokinin can inhibit the infection thread progression.