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Sp1 inhibits PDSS2 gene expression. Overexpression of Sp1 inhibits PDSS2 promoter activity, both in A549 (a) and H1299 (b) cells. Exogenous expression of Sp1 represses endogenous PDSS2 expression, both at mRNA levels (c) and protein levels (d). GAPDH was used as an internal control (* 0.01 < p < 0.05, ** p < 0.01, *** p < 0.001).
