Figure 1.

Erastin decreases mortality and organ damage in a CLP-induced sepsis model. (A) Mice were subjected to CLP or sham operation, then administrated i.p. injection with or without 20 mg/kg erastin after CLP. All groups, n = 10. Mortality of each group was monitored daily for 5 days after surgery operation: sham (circle), DMSO (square), and erastin (empty square). The serum levels of (B) alanine aminotransferase (ALT) and (C) blood urea nitrogen (BUN) were measured in the sham and CLP model with or without erastin administration. All groups, n = 6. Mouse serum samples were collected at 24 h after CLP with or without erastin administration. Graphs represent mean of five independent mice. Statistical analyses were performed using paired two-tailed Student’s t-test. * p < 0.05, # p < 0.01.