Table 1.

Hypoxia-inducible factor (HIF)-related non-coding RNAs (ncRNAs) in gastric cancer (GC).

Non-coding RNAs	Functions	Targets	Ref.
miR-18a	Promotes apoptosis and reduces cell invasion by regulating HIF-1α	HIF-1α	[23]
miR-186	Directly regulates HIF-1α and inhibits cell proliferation	HIF-1α	[24]
miR-143	Directly regulates HIF-1α	HIF-1α, ZEB2-AS1	[25]
PVT1	Enhances multidrug resistance and is associated with lymph node metastasis	HIF-1α, MDR1, MRP, mTOR	[26,27]
miR-320	Upregulated by crocin and regulates HIF-1α by inhibiting KLF5	KLF5	[28]
miR-210	Regulates chemoresistance, invasion, and metastasis (HRE region in miR-210 promoter 1)	HOXA9	[29,30]
miR-382	Enhances angiogenesis (HRE region in miR-382 promoter 1)	PTEN	[32,33]
miR-107	Upregulated in GC serum and tissue samples		[34]
miR-27a	Regulates cell proliferation and drug resistance (HRE region in miR-27a promoter 1)		[35]
miR-421	Upregulated in GC tissues. Regulates metastasis and cisplatin resistance (HRE region in miR-421 promoter 1)	CDH1, CASP3	[36]
miR-214	Upregulated in GC tissues. Enhances cell proliferation and migration	A2AR, PRDM16	[37]
miR-224	Regulates cell proliferation and migration (HRE region in miR-224 promoter 1)	RASFF8	[38]
UCA1	Promotes hypoxia-induced cell migration	miR-7-5p	[39]
BC005927	Upregulated in GC and is associated with poor prognosis. Promotes metastasis (HRE region in lncRNA promoter 1)	EPHB4	[40]
PCGEM1	Regulates GC cell invasion, metastasis, and EMT	SNAI1	[41]
GAPLINC	Upregulated in GC and is associated with poor prognosis (HRE region in lncRNA promoter 1)		[42]
AK123072	Upregulated in GC tissues. Regulates cell migration and invasion		[43]
AK053003	Regulates GC cell migration and invasion	SNCG	[44]

¹ Mechanism of regulation by HIFs.