Table 2.
HIF-related ncRNAs in colorectal cancer (CRC).
| Non-coding RNAs | Functions | Targets | Ref. |
|---|---|---|---|
| miR-210, miR-21 | Regulates HIF-1α/ VEGF signaling pathways to initiate colon cancer. | [45] | |
| miR-200b | Directly regulates HIF-1α and regulatory feedback for CRC EMT-MET plasticity. | HIF-1α | [46] |
| miR-199a | Reduces HIF-1α/VEGF expression and suppresses CRC proliferation, migration, and invasion. | [47] | |
| miR-31 | Reduces FIH expression and is associated with CRC development. | FIH-1 | [49] |
| miR-22 | Down-regulates HIF-1α and represses cell growth and invasion in CRC. | HIF-1α | [50] |
| miR-107 | Reduces HIF-1β expression and down-regulates tumor growth, VEGF expression, and angiogenesis. | HIF-1β | [51] |
| miR-145 | Down-regulates HIF-1α and VEGF expression and represses cell growth and angiogenesis in CRC. | p70S6K1 | [52] |
| lncRNA CPS1-IT1 | Inhibits HIF-1α activation and suppresses EMT and autophagy. | [53] | |
| miR-23a, miR27a, miR-24 | Regulates glucose association via TCA-related genes under hypoxic conditions (HRE1, HRE2 in miRNA promoter 1). | [54] | |
| miR-210 | Reduces radiosensitivity by inducing autophagy in CRC. | Bcl-2 | [56] |
| miR-338-5p | Reduces hypoxia-induced drug resistance by regulating IL-6. | IL-6 | [58] |
| lncRNA HOTAIR | Regulates tumor growth under hypoxic conditions in CRC (HRE region in lncRNA promoter 1). | [59] | |
| miR-15-16 | Regulates tumor metastasis and angiogenesis (Indirect target of HIF-2α 1). | FGF-2 | [60] |
1 Mechanism of regulation by HIFs