Skip to main content
. 2019 Nov 21;8(12):2047. doi: 10.3390/jcm8122047

Table 1.

The receptors/molecules that are suggested to be involved in efferocytosis.

Steps. References Molecules
Find-Me signal [24,25,36] LysoPC, ATP, P2Y2, ApoJ, ApoE4, Fractalkine (CX3CL1), S1P
Don’t Eat Me and Eat-Me signals CD31, CD47, PtdSer, Caspase, MFG-E8, MerTK, Gas6, Protein S,
Engulfment and processing TRPC3, ABCA7, IRF8, IRF5, PPAR-δ/γ, p38 MAPK activities, CDKN2B, TLR3, TRAF6, UCP2, Cathepsin G, Rac
Anti-inflammatory and tolerance responses TGF-β, IL-10

Abbreviations: ABCA7: ATP-binding cassette transporter A7; ApoE: apolipoprotein E; ATP: adenosine triphosphate; CD: cluster differentiation; CDKN2B: cyclin-dependent kinase inhibitor 2B; Gas6: growth arrest-specific 6; IRF5: interferon regulatory factor 5; IRF8: interferon regulatory factor 8; LysoPC: lysophosphatidylcholine; MAPK: mitogen-activated kinase-like protein; MerTK: mer tyrosine kinase; MFG-E8: milk fat globule-EGF factor 8; PPAR-δ/γ: peroxisome proliferator-activated receptor delta/gamma; PtdSer: phosphatidylserine; Rac: a family small GTPase; S1P: sphingosine-1-phosphate; TLR3: toll-like receptor 3; TRAF6: tumor necrosis factor receptor-associated factor 6; TRPC3: transient receptor potential canonical 3; UCP2: uncoupling protein 2.