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. 2019 Dec 11;8(12):2182. doi: 10.3390/jcm8122182

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Forest plots of network meta-analysis of all trials for efficacy and safety. Antibiotics versus amoxicillin (reference drug). OR = odds ratio. CI = confidence interval. Colorful rectangles represent the ORs. Black lines represent the range of 95% CIs. For efficacy, an OR higher than 1 means the efficacy of a certain drug is better than that of amoxicillin. For safety, an OR higher 1 means the safety of a certain drug is worse than that of amoxicillin. The differences in efficacy or safety can be regarded as a significant when the range of the 95% CI does not include 1. In other words, it means there is significant difference between a certain drug and amoxicillin. (A) comparisons of injectable drugs for efficacy. (B) Comparisons of oral drugs for efficacy. (C) Comparisons of injectable drugs for safety. (D) Comparisons of oral drugs for safety.