. 2019 Nov 21;8(12):2034. doi: 10.3390/jcm8122034

Table A2.

Comparison (via McNemar’s test) of drug indications based on the glomerular filtration rate estimated with different formulae.

	By CG		By CKD-EPI				p	By MDRD				p
			Reduced		Standard			Reduced		Standard
			On	Off	On	Off		On	Off	On	Off
All DOACs	Reduced	On	635	142	0	0	<0.05	633	144	0	0	<0.05
	Reduced	Off	12	721	0	0		12	721	0	0
	Standard	On	0	0	1863	10		0	0	1861	12
	Standard	Off	0	0	62	164		0	0	62	164
Dabigatran	Reduced	On	169	16	0	0	<0.05	169	16	0	0	<0.05
	Reduced	Off	6	114	0	0		6	114	0	0
	Standard	On	0	0	476	2		0	0	476	2
	Standard	Off	0	0	14	52		0	0	14	52
Rivaroxaban	Reduced	On	58	79	0	0	<0.05	57	80	0	0	<0.05
	Reduced	Off	2	182	0	0		2	182	0	0
	Standard	On	0	0	257	2		0	0	256	3
	Standard	Off	0	0	28	17		0	0	28	17
Apixaban	Reduced	On	89	8	0	0	<0.05	89	8	0	0	<0.05
	Reduced	Off	0	218	0	0		0	218	0	0
	Standard	On	0	0	636	0		0	0	636	0
	Standard	Off	0	0	3	9		0	0	3	9
Edoxaban	Reduced	On	319	39	0	0	<0.05	318	40	0	0	<0.05
	Reduced	Off	4	207	0	0		4	207	0	0
	Standard	On	0	0	494	6		0	0	493	7
	Standard	Off	0	0	17	86		0	0	17	86

Abbreviations: CG, Cockcroft-Gault formula; CKD-EPI, Chronic Kidney Disease Epidemiology Collaboration formula; DOAC, direct oral anticoagulant; MDRD, Modification of Diet in Renal Disease Study formula; Off, off-label; On, on-label.