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Ambler classification of β‐lactamases. A) Class A (extended spectrum), C (AmpC enzymes), and D (oxacillinase family): serine β‐lactamases‐mediated inactivation involves the attack of a nucleophilic serine. B) Class B (metallo): β‐lactam inactivation mediated by metallo‐β‐lactamases is facilitated by a nucleophilic attack via an activated water molecule coordinated to zinc ions. Reproduced with permission.103 Copyright 2010, Royal Society of Chemistry.
