Table 2.
Comparison of baseline characteristics between the subgroups of patients with osteoporosis versus those without osteoporosis.
| Osteoporosis | No Osteoporosis | p-Value | |
|---|---|---|---|
| Variable | n = 78 | n = 315 | |
| Male, n (%) | 43 (55.1) | 132 (41.9) | 0.035 1 |
| Age at diagnosis of CD (years), median (range) | 23 (8–66) | 23 (9–68) | 0.413 2 |
| Age at first DXA scan (years), median (range) | 44 (18–77) | 34 (18–75) | 0.009 2 |
| Montreal classification of CD: | |||
| Age | 0.028 1 | ||
| A1 | 10 (13.0) | 35 (11.1) | |
| A2 | 52 (67.5) | 250 (79.6) | |
| A3 | 15 (19.5) | 29 (9.2) | |
| Location | 0.462 1 | ||
| L1 | 24 (31.2) | 92 (29.2) | |
| L2 | 7 (9.1) | 50 (15.9) | |
| L3 | 46 (59.7) | 172 (54.6) | |
| L4 | 5 (6.5) | 33 (10.5) | 0.290 1 |
| Behavior | 0.816 1 | ||
| B1 | 25 (32.1) | 107 (43.2) | |
| B2 | 17 (21.8) | 74 (23.6) | |
| B3 | 36 (46.2) | 132 (42.2) | |
| Disease duration at first DXA scan (years), median (range) | 10.5 (0–61) | 8 (0–40) | 0.028 2 |
| Presence of at least one extraintestinal manifestation, n (%) | 42 (53.8) | 169 (53.7) | 0.975 1 |
| Active cigarette smoking at first DXA scan, n (%) | 28 (36.8) | 118 (38.9) | 0.736 1 |
| BMI (kg/m²), mean ± SD (range) | 21.3 ± 4.2 (14.6–33.3) | 24.9 ± 5.0 (15.2–45.7) | <0.001 2 |
| History of anti-TNFα treatment, n (%) | 15 (19.2) | 76 (24.1) | 0.359 1 |
| History of anti-integrin treatment, n (%) | 2 (2.6) | 1 (0.3) | 0.042 1 |
| History of immunomodulator treatment, n (%) | 28 (35.9) | 115 (36.5) | 0.920 1 |
| History of bowel resection(s), n (%) | 66 (84.6) | 202 (64.1) | 0.001 1 |
| Short bowel syndrome, n (%) | 5 (6.4) | 2 (0.6) | 0.001 1 |
| Ostomy, n (%) | 8 (10.3) | 18 (5.7) | 0.148 1 |
BMI: body mass index; CD: Crohn’s disease; DXA: dual-energy X-ray absorptiometry; SD: standard deviation; TNFα: Tumor necrosis factor alpha; 1 Chi-squared test; 2 Mann–Whitney test; Montreal classification of Crohn’s disease: A1: age < 16 years; A2: age 17–40 years; A3: age > 40 years; L1: location ileal; L2: location colonic; L3: location ileal and colonic; L4: location upper gastrointestinal tract; B1: non-stricturing non penetrating behavior; B2: stricturing behavior; B3: penetrating behavior.