Figure 3.

Interactions with DNA repair proteins are affected by DNA damage. Changes in enrichment determined by LFQ analysis are shown as volcano plots with the log₁₀ of the fold change after etoposide treatment (x-axis) vs the log₁₀ of p-values of the change for interactors shared by TDP-43 (A) and FUS (B). At the top are changes in all shared interactors detected at levels significantly above controls. Second, interactors are superimposed from the RNA exosome and transcription-coupled nucleotide repair machinery, including the RFC complex. Third, interactors that are members of the cytosolic and mitochondrial ribosomes are shown. Last are proteins classified as chromatin-bound and the few transcription-related proteins shared by FUS and TDP-43. The identity of the interactors plotted is found in Table 1. Interactors unique to TDP-43 or FUS are included in Figure 1B,C and Table 1.