Table 1.

A Comparison of Current Scalable Technologies.

	Shared-Memory Multicore Architecture	Special Hardware	HPC	Cloud	Container Orchestration
Ease of dev	+++	+	+	++	+++
Robustness	++	++	+	+++	+++
Scalability	+	+	+++	+++	+++
Efficiency	++	+++	++	+	+
Representative Software	SPAdes [9], OpenMP LCS [11], ALLPATHS-LG [12], SOAPdenovo [13], LSHvec [57]	FAGP [17], SOAP3 [58], SOAP3-dp [59], CUSHAW2-GPU [60] FPGA-based Smith-Waterman [61]	pBWA [27], Ray [28], Meta-HipMer [32] ClustalW-MPI [62] TREE-PUZZLE [63]	HAlign [37] BigBWA [38], BioPig [40,41], SpaRC [46], Metaspark [47], SparkBWA [64]	Galaxy-Kubernetes [53]