Table 2.
Analyses of the EPHX2, NPY5R, ANO2, NRG1, FKBP5, RORA, OXTR and BDNF genotype among women with GDM were stratified by psychological symptoms.
| Candidate Genes | SNP | Genotype | Normal | Presence of Depression Symptoms | p-Value | Normal | Presence of Anxiety Symptoms | p-Value | Normal | Presence of Stress Symptoms | p-Value |
|---|---|---|---|---|---|---|---|---|---|---|---|
| EPHX2 | rs17466684 | GG | 223 (75.1) | 36 (78.3) | 0.122 | 155 (78.7) | 104 (71.2) | 0.267 | 228 (75.2) | 31 (77.5) | 0.078 |
| GA | 68(22.9) | 7 (15.2) | 38(19.3) | 37 (25.3) | 69 (22.8) | 6 (15.0) | |||||
| AA | 6 (2.0) | 3 (6.5) | 4 (2.0) | 5 (3.5) | 6 (2.0) | 3 (7.5) | |||||
| GG genotype | 223 (75.1) | 36 (78.3) | 0.641 | 155 (78.7) | 104 (71.2) | 0.113 | 228 (75.2) | 31 (77.5) | 0.756 | ||
| A carrier | 74 (24.9) | 10 (21.7) | 42 (21.3) | 42 (28.8) | 75 (24.8) | 9 (22.5) | |||||
| G carrier | 291 (98.0) | 43 (93.5) | 0.106 * | 193 (98.0) | 141 (96.6) | 0.504 * | 297 (98.0) | 37 (92.5) | 0.075 * | ||
| AA genotype | 6 (2.0) | 3 (6.5) | 4 (2.0) | 5 (3.4) | 6 (2.0) | 3 (7.5) | |||||
| NPY5R | rs12501691 | TT | 202 (68.0) | 32 (69.5) | 0.972 | 137 (69.6) | 97 (66.4) | 0.550 | 202 (66.7) | 32 (80.0) | 0.197 |
| TA | 89 (30.0) | 13 (28.3) | 55 (27.9) | 47 (32.2) | 95 (31.3) | 7 (17.5) | |||||
| AA | 6 (2.0) | 1 (2.2) | 5 (2.5) | 2 (1.4) | 6 (2.0) | 1 (2.5) | |||||
| TT genotype | 202 (68.0) | 32 (69.6) | 0.833 | 137 (69.5) | 97 (66.4) | 0.541 | 202 (66.7) | 32 (80.0) | 0.089 | ||
| A carrier | 95 (32.0) | 14 (30.4) | 60 (30.5) | 49 (33.6) | 101 (33.3) | 8 (20.0) | |||||
| T carrier | 291 (98.0) | 45 (97.8) | 1.000 | 192 (97.5) | 144 (98.6) | 0.703 * | 297 (98.0) | 39 (97.5) | 0.584 | ||
| AA genotype | 6 (2.0) | 1 (2.2) | 5 (2.5) | 2 (1.4) | 6 (2.0) | 1 (2.5) | |||||
| ANO2 | rs12579350 | GG | 261 (87.9) | 36(78.3) | 0.107 | 168 (85.3) | 129 (88.3) | 0.704 | 263 (86.8) | 34 (85.0) | 0.730 |
| GA | 33 (11.1) | 10 (21.7) | 27 (13.7) | 16 (11.0) | 37 (12.2) | 6 (15.0) | |||||
| AA | 3 (1.0) | 0 (0.0) | 2 (1.0) | 1 (0.7) | 3 (1.0) | 0 (0.0) | |||||
| GG genotype | 261 (87.9) | 36 (78.3) | 0.075 | 168 (85.3) | 129 (88.4) | 0.408 | 263 (86.8) | 34 (85.0) | 0.754 | ||
| A carrier | 36 (12.1) | 10 (21.7) | 29 (14.7) | 17 (11.6) | 40 (13.2) | 6 (15.0) | |||||
| G carrier | 294 (99.0) | 46 (100.0) | 1.000 | 195 (99.0) | 145 (99.3) | 1.000 * | 300 (99.0) | 40 (100.0) | 1.000 | ||
| AA genotype | 3 (1.0) | 0 (0.0) | 2 (1.0) | 1 (0.7) | 3 (1.0) | 0 (0.0) | |||||
| NRG1 | rs2919375 | TT | 119 (40.2) | 18 (39.1) | 0.812 | 78 (39.8) | 59 (40.4) | 0.981 | 119 (39.4) | 18 (45.0) | 0.097 |
| TC | 136 (45.9) | 23 (50.0) | 92 (46.9) | 67 (45.9) | 138 (45.7) | 21 (52.5) | |||||
| CC | 41 (13.9) | 5 (10.9) | 26 (13.3) | 20 (13.7) | 45 (14.9) | 1 (2.5) | |||||
| TT genotype | 119 (40.2) | 18 (39.1) | 1.000 | 78 (39.8) | 59 (40.4) | 0.909 | 119 (39.4) | 18 (45.0) | 0.497 | ||
| C carrier | 177 (59.8) | 28 (60.9) | 118 (60.2) | 87 (59.6) | 183 (60.6) | 22 (55.0) | |||||
| T carrier | 255 (86.1) | 41 (89.1) | 0.581 | 170 (86.7) | 126 (86.3) | 0.908 | 257 (85.1) | 39 (97.5) | 0.031 * | ||
| CC genotype | 41 (13.9) | 5 (10.9) | 26 (13.3) | 20 (13.7) | 45 (14.9) | 1 (2.5) | |||||
| FKBP5 | rs3800373 | TT | 122 (41.8) | 23 (50.0) | 0.097 | 82 (42.5) | 63 (43.4) | 0.982 | 122 (40.9) | 23 (57.5) | 0.103 |
| TG | 146 (50.0) | 16 (34.8) | 93 (48.2) | 69 (47.6) | 149 (50.0) | 13 (32.5) | |||||
| GG | 24 (8.2) | 7 (15.2) | 18 (9.3) | 13 (9.0) | 27 (9.1) | 4 (10.0) | |||||
| TT genotype | 122 (41.8) | 23 (50.0) | 0.295 | 82 (42.5) | 63 (43.4) | 0.86 | 122 (40.9) | 23 (57.5) | 0.047 | ||
| G carrier | 170 (58.2) | 23 (50.0) | 111 (57.5) | 82 (56.6) | 176 (59.1) | 17 (42.5) | |||||
| T carrier | 268 (91.8) | 39 (84.8) | 0.164 * | 175 (90.7) | 132 (91.0) | 0.909 | 271 (90.9) | 36 (90.0) | 0.774 | ||
| GG genotype | 24 (8.2) | 7 (15.2) | 18 (9.3) | 13 (9.0) | 27 (9.1) | 4 (10.0) | |||||
| RORA | rs4775340 | GG | 186 (62.9) | 31 (67.4) | 0.775 | 127 (64.5) | 90 (62.1) | 0.818 | 188 (62.3) | 29 (72.5) | 0.449 |
| GA | 99 (33.4) | 14 (30.4) | 65 (32.5) | 49 (33.8) | 103 (34.1) | 10 (25.0) | |||||
| AA | 11 (3.7) | 1 (2.2) | 6 (3.0) | 6 (4.1) | 11 (3.6) | 1 (2.5) | |||||
| GG genotype | 186 (62.8) | 31 (67.4) | 0.551 | 127 (64.5) | 90 (62.1) | 0.649 | 188 (62.3) | 29 (72.5) | 0.206 | ||
| A carrier | 110 (37.2) | 15 (32.6) | 70 (35.5) | 55 (37.9) | 114 (37.7) | 11 (27.5) | |||||
| G carrier | 285 (96.3) | 45 (97.8) | 1.000 * | 191 (97.0) | 139(95.9) | 0.587 | 291 (96.4) | 39 (97.5) | 1.000 * | ||
| AA genotype | 11 (3.7) | 1 (2.2) | 6 (3.0) | 6 (4.1) | 11 (3.6) | 1 (2.5) | |||||
| OXTR | rs53576 | AA | 76 (25.7) | 16 (34.8) | 0.137 | 49(24.9) | 43(29.7) | 0.611 | 81 (26.8) | 11 (27.5) | 0.337 |
| AG | 114 (48.6) | 24 (52.2) | 99 (50.3) | 69 (47.6) | 145 (48.0) | 23 (57.5) | |||||
| GG | 76 (25.7) | 6 (13.0) | 49 (24.9) | 33 (22.8) | 76 (25.2) | 6 (15.0) | |||||
| AA genotype | 76 (25.7) | 16 (34.8) | 0.195 | 49 (24.9) | 43 (29.7) | 0.324 | 81 (26.8) | 11 (27.5) | 1.000 * | ||
| G carrier | 220 (74.3) | 30 (65.2) | 148 (75.1) | 102 (70.3) | 221 (73.2) | 29 (72.5) | |||||
| A carrier | 220 (74.3) | 40 (87.0) | 0.062 | 148 (75.1) | 112 (77.2) | 0.651 | 226 (74.8) | 34 (85.0) | 0.157 | ||
| GG genotype | 76 (25.7) | 6 (13.0) | 49 (24.9) | 33 (22.8) | 76 (25.2) | 6 (15.0) | |||||
| BDNF | rs6265 | GG | 95 (32.1) | 19 (42.2) | 0.361 | 62 (31.4) | 52 (36.1) | 0.646 | 96 (31.9) | 18 (45.0) | 0.230 |
| GA | 145 (49.0) | 20 (44.4) | 99 (50.3) | 66 (45.8) | 148 (49.2) | 17 (42.5) | |||||
| AA | 56 (18.9) | 6 (13.3) | 36 (18.3) | 26 (18.1) | 57 (18.9) | 5 (12.5) | |||||
| GG genotype | 95 (32.1) | 19 (42.2) | 0.180 | 62 (31.5) | 52 (36.1) | 0.370 | 96 (31.9) | 18 (45.0) | 0.099 | ||
| A carrier | 201 (67.9) | 26 (57.8) | 135 (68.5) | 92 (63.9) | 205 (68.1) | 22 (55.0) | |||||
| G carrier | 240 (81.1) | 39 (86.7) | 0.365 | 161 (81.7) | 118 (81.9) | 0.959 | 244 (81.1) | 35 (87.5) | 0.321 | ||
| AA genotype | 56 (18.9) | 6 (13.3) | 36 (18.3) | 26 (18.1) | 57 (18.9) | 5 (12.5) | |||||
| FKBP5 | rs9470080 | CC | 128 (43.0) | 22 (47.8) | 0.681 | 85 (42.9) | 65 (44.5) | 0.953 | 127 (41.8) | 23 (57.5) | 0.160 |
| CT | 137 (46.0) | 18 (39.2) | 90 (45.5) | 65 (44.5) | 142 (46.7) | 13 (32.5) | |||||
| TT | 33 (11.0) | 6 (13.0) | 23 (11.6) | 16 (11.0) | 35 (11.5) | 4 (10.0) | |||||
| CC genotype | 128 (43.0) | 22 (47.8) | 0.535 | 85 (42.9) | 65(44.5) | 0.769 | 127 (41.8) | 23 (57.5) | 0.059 | ||
| T carrier | 170 (57.0) | 24 (52.2) | 113 (57.1) | 81 (55.5) | 177 (58.2) | 17 (42.5) | |||||
| C carrier | 265 (88.9) | 40 (87.0) | 0.695 | 175 (88.4) | 130 (89.0) | 0.849 | 269 (88.5) | 36 (90.0) | 1.000 * | ||
| TT genotype | 33 (11.1) | 6 (13.0) | 23 (11.6) | 16 (11.0) | 35 (11.5) | 4 (10.0) |
Note: * p-value based on fisher’s exact test.