Table 3.
Multiple regression analysis between genotypes of candidate genes and the presence of psychological symptoms adjusted for the confounding factors (n = 343).
| Candidate Genes SNP |
Geno-Types | Depression Symptoms | Geno-Types | Anxiety Symptoms | Geno-Types | Stress Symptoms | |||
|---|---|---|---|---|---|---|---|---|---|
| Crude OR (95% CI), p-Value |
Adjusted OR (95% CI), p-Value |
Crude OR (95% CI), p-Value |
Adjusted OR (95% CI), p-Value |
Crude OR (95% CI), p-Value |
Adjusted OR (95% CI), p-Value |
||||
|
EPHX2
rs17466684 |
GG/GA | 1 | 1 | GG | 1 | 1 | GG/GA | 1 | 1 |
| AA | 3.846 (0.852–17.353), 0.080 |
7.854 (1.330–46.360), 0.023 |
AA/AG | 1.490 (0.909–2.444), 0.114 |
1.580 (0.943–2.659), 0.083 |
AA | 4.622 (0.964–22.158), 0.056 |
7.664 (1.579–37.197), 0.012 |
|
|
ANO2
rs12579350 |
GG | 1 | 1 | - | - | - | - | - | - |
| AA/AG | 2.037 (0.907–4.573), 0.085 |
1.880 (0.655–5.393), 0.240 |
- | - | - | - | - | - | |
|
FKBP5
rs3800373 |
TT/TG | 1 | 1 | - | - | - | GG/GT | 1 | 1 |
| GG | 1.879 (0.729–4.841), 0.192 |
2.497 (0.746–8.359), 0.138 |
- | - | - | TT | 1.446 (0.255–8.193), 0.677 |
1.963 (0.952–4.045), 0.068 |
|
|
OXTR
rs53576 |
GG | 1 | 1 | - | - | - | GG | 1 | 1 |
| AA/AG | 2.490 (0.988–6.274), 0.053 |
2.114 (0.704–6.348), 0.182 |
- | - | - | AA/AG | 2.228 (0.8595–5.779), 0.099 |
2.981 (1.058–8.402), 0.039 |
|
|
BDNF
rs6265 |
AA/AG | 1 | 1 | - | - | - | AA/AG | 1 | 1 |
| GG | 1.498 (0.778–2.885), 0.227 |
1.045 (0.429–2.548), 0.922 |
- | - | - | GG | 1.883 (0.932–3.802), 0.078 |
1.651 (0.786–3.468), 0.185 |
|
|
NPY5R
rs12501691 |
- | - | - | - | - | - | AA/AT | 1 | 1.000 |
| - | - | - | - | - | - | TT | 2.206 (0.948–5.136),0.066 |
2.182 (0.915–5.204), 0.079 |
|
|
NRG1
rs2919375 |
- | - | - | - | - | - | CC | 1 | 1 |
| - | - | - | - | - | - | TT/TC | 7.752 (1.000–60.105), 0.050 |
9.894 (1.159–84.427), 0.036 |
|
| FKBP5 rs9470080 | - | - | - | - | - | - | TT/TC | 1 | 1 |
| - | - | - | - | - | - | CC | 1.539 (0.271–8.739), 0.627 |
1.118 (0.161–7.762), 0.910 |
|
|
RORA
rs4775340 |
- | - | - | - | - | - | AA/AG | 1 | 1 |
| - | - | - | - | - | - | GG | 1.822 (0.848–3.914), 0.124 |
1.790 (0.789–4.061), 0.164 |
|
Note: Adjusted OR was determined by adjusting for socio-demographical and clinical moderators with p-value < 0.25 in univariate analysis.