Table A3.
Analyses of the genotype of LHPP, SDK2, HTR2C, TEX51, PLEKHG1 and TPH2 among women with GDM were stratified by presence of psychological symptoms. * p-value based on fisher’s exact test.
| Candidate Genes | SNP | Genotype | Normal | Presence of Depression Symptoms | p-Value | Normal | Presence of Anxiety Symptoms | p-Value | Normal | Presence of Stress Symptoms | p-Value |
|---|---|---|---|---|---|---|---|---|---|---|---|
| LHPP | rs35936514 | CC | 139 (85.8) | 23 (14.2) | 0.600 | 97 (59.9) | 65 (40.1) | 0.262 | 144 (88.9) | 18 (11.1) | 0.909 |
| CT | 123 (86.0) | 20 (14.0) | 75 (52.4) | 68 (47.6) | 125 (87.4) | 18 (12.6) | |||||
| TT | 34 (91.9) | 3 (8.1) | 24 (64.9) | 13 (35.1) | 33 (89.2) | 4 (10.8) | |||||
| CC genotype | 139 (85.8) | 23 (14.2) | 0.701 | 97 (59.9) | 65 (40.1) | 0.363 | 144 (88.9) | 18 (11.1) | 0.750 | ||
| T carrier | 157 (87.2) | 23 (12.8) | 99 (55.0) | 81 (45.0) | 158 (87.8) | 22 (12.2) | |||||
| C carrier | 262 (85.9) | 43 (14.1) | 0.445 * | 172(56.4) | 133 (43.6) | 0.325 | 269 (88.2) | 36 (11.8) | 1.000 * | ||
| TT genotype | 34 (91.9) | 3 (8.1) | 24 (65.9) | 13 (35.1) | 33 (89.2) | 4 (10.8) | |||||
| SDK2 | rs3816995 | GG | 183 (86.7) | 28 (13.3) | 0.910 | 119 (56.4) | 92 (43.6) | 0.735 | 187 (88.6) | 24 (11.4) | 0.920 |
| GA | 96 (86.5) | 15 (13.5) | 65 (58.6) | 46 (41.4) | 97 (87.4) | 14 (12.6) | |||||
| AA | 18 (90.0) | 2 (10.0) | 13 (65.0) | 7 (35.0) | 18 (90.0) | 2 (10.0) | |||||
| GG genotype | 183 (86.7) | 28 (13.3) | 0.938 | 119 (56.4) | 92 (43.6) | 0.567 | 187 (88.6) | 24 (11.4) | 0.814 | ||
| A carrier | 114 (87.0) | 17 (13.0) | 78 (59.5) | 53 (40.5) | 115 (87.8) | 16 (12.2) | |||||
| G carrier | 279 (86.6) | 43 (13.4) | 1.000 * | 184 (57.1) | 138 (42.9) | 0.490 | 284 (88.2) | 38 (11.8) | 1.000 * | ||
| AA genotype | 18 (90.0) | 2 (10.0) | 13 (65.0) | 7 (35.0) | 18 (90.0) | 2 (10.0) | |||||
| HTR2C | rs6318 | GG | 279 (86.4) | 44 (13.6) | 0.883 | 187 (57.9) | 136 (42.1) | 0.496 * | 286 (88.5) | 37 (11.5) | 0.748 |
| GC | 16 (88.9) | 2 (11.1) | 10 (55.6) | 8 (44.4) | 15 (83.3) | 3 (16.7) | |||||
| CC | 1 (100.0) | 0 (0.0) | 0 (0.0) | 1 (100.0) | 1 (100.0) | 0 (0.0) | |||||
| GG genotype | 279 (86.4) | 44 (13.6) | 1.000 * | 187 (57.9) | 136 (42.1) | 0.652 | 286 (88.5) | 37 (11.5) | 0.475 * | ||
| C carrier | 17 (89.5) | 2 (10.5) | 10 (52.6) | 9 (47.4) | 16 (84.2) | 3 (15.8) | |||||
| G carrier | 295 (86.5) | 46 (13.5) | 1.000 * | 197 (57.8) | 144 (42.2) | 0.424 * | 301 (88.3) | 40 (11.7) | 1.000 * | ||
| CC genotype | 1 (100.0) | 0 (0.0) | 0 (0.0) | 1 (100.0) | 1(100.0) | 0 (0.0) | |||||
| TEX51 | rs6733840 | TT | 189 (86.3) | 30 (13.7) | 0.977 | 125 (57.1) | 94 (42.9) | 0.914 | 191 (87.2) | 28 (12.8) | 0.643 |
| TC | 94 (87.0) | 14 (13.0) | 62 (57.4) | 46 (42.6) | 98 (90.7) | 10 (9.3) | |||||
| CC | 14 (87.5) | 2 (12.5) | 10 (62.5) | 6 (37.5) | 14 (87.5) | 2 (12.5) | |||||
| TT genotype | 189 (86.3) | 30 (13.7) | 0.835 | 125 (57.1) | 94 (42.9) | 0.859 | 191 (87.2) | 28 (12.8) | 0.389 | ||
| C carrier | 108 (87.1) | 16 (12.9) | 72 (58.1) | 52 (41.9) | 112 (90.3) | 12 (9.7) | |||||
| T carrier | 282 (86.5) | 44 (13.5) | 1.000 * | 187 (57.2) | 140 (42.8) | 0.675 | 289 (88.4) | 38 (11.6) | 1.000 * | ||
| CC genotype | 14 (87.5) | 2 (12.5) | 10 (62.5) | 6 (37.5) | 14 (87.5) | 2 (12.5) | |||||
| PLEKHG1 | rs9372078 | AA | 115 (87.1) | 17 (12.9) | 0.951 | 75 (56.8) | 57 (43.2) | 0.878 | 118 (89.4) | 14 (10.6) | 0.763 |
| AT | 138 (86.3) | 22 (13.8) | 95 (59.4) | 65 (40.6) | 139 (86.9) | 21 (13.1) | |||||
| TT | 41 (85.4) | 7 (14.6) | 27 (56.3) | 21 (43.8) | 43 (89.6) | 5 (10.4) | |||||
| AA genotype | 115 (87.1) | 17 (12.9) | 0.780 | 75 (56.8) | 57 (43.2) | 0.738 | 118 (89.4) | 14 (10.6) | 0.597 | ||
| T carrier | 179 (86.1) | 29 (13.9) | 122 (58.7) | 86 (41.3) | 182 (87.5) | 26 (12.5) | |||||
| A carrier | 253 (86.6) | 39 (13.4) | 0.818 | 170 (58.2) | 122 (41.8) | 0.798 | 257 (88.0) | 35 (12.0) | 0.754 | ||
| TT genotype | 41 (85.4) | 7 (14.6) | 27 (56.3) | 21 (43.8) | 43 (89.6) | 5 (10.4) | |||||
| TPH2 | rs1843809 | TT | 269 (86.2) | 43 (13.8) | 0.398 * | 179(57.4) | 133 (42.6) | 0.896 | 274 (87.8) | 38 (12.2) | 0.553 * |
| TG | 27 (93.1) | 2 (6.9) | 17 (58.6) | 12 (41.4) | 27 (93.1) | 2 (6.9) | |||||
| GG | 0 (0.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) | |||||
| TT genotype | - | - | - | - | - | - | |||||
| G carrier | - | - | - | - | - | - | |||||
| T carrier | - | - | - | - | - | - | |||||
| GG genotype | - | - | - | - | - | - |