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. 2019 Dec 2;10(12):999. doi: 10.3390/genes10120999

Figure 2.

Figure 2

Methylation-imprint maintenance requires KRüppel Associated Box (KRAB)-domain zinc finger proteins. In the mouse, different imprinting control regions (ICRs) are bound by different KRAB domain zinc finger proteins (ZFPs) on the DNA-methylated allele, which maintains allelic DNA methylation and allelic gene expression. The ICR of the mouse Igf2-H19 domain comprises binding sites for both ZFP57 and ZFP445, whereas the ICR of the Snrpn domain (‘Prader-Willi Syndrome domain’ in humans) has a recognition sequence motif for ZFP57 only. It is unknown which ZFP is recruited to the methylated allele of the ICR of the mouse Peg10/Sgce imprinted domain.