Skip to main content
. 2019 Nov 29;10(12):987. doi: 10.3390/genes10120987

Figure 7.

Figure 7

Schematic picture of the localization of the CRB proteins in mammalian adult retinal Müller glial and photoreceptor cells. (A–E) CRB1 (red) and CRB2 (blue) proteins localize at the subapical region in mouse (A) and human (B) retinal progenitors cells and adult Müller glial cells of mice (C), non-human primates (D) and humans (E). However, the expression of CRB1 in the early developing human retina is low and sporadic. Additionally, the expression patterns of CRB1 and CRB2 at the subapical region of adult photoreceptors differs between the three species. CRB2 is present at the subapical region of mouse photoreceptors, whereas CRB1 is not (C). In non-human primates both CRB1 and CRB2 are present in photoreceptors (D). In cadaveric human retinas collected 2-days after death CRB1 is present at the subapical region whereas CRB2 is present in the photoreceptor inner segments but at some distance from the subapical region (E). PRC: Photoreceptor; MGC: Müller glial cells.