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. 2019 Nov 29;10(12):987. doi: 10.3390/genes10120987

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Disruptions at the outer limiting membrane in retinal organoids from CRB1 retinitis pigmentosa (RP) patients. Schematic depiction of healthy (A) and CRB1 patient (B,C) derived retinal organoids. (A) In healthy organoids CRB1 is located at the subapical region adjacent to the adherens junctions. (B,D) In retinal organoids from CRB1 retinitis pigmentosa patient (LUMC0116iCRB) disruptions of the outer limiting membrane (OLM) and ectopic photoreceptors have been found. (C,E) Additionally, budding of the apical membrane and mislocalization of the CRB1 variant in the NBL also occurs. Scale bars (D,E), 20 µm. Panels (C,D) are modified from [178] under a Creative Commons license.