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. 2019 Nov 13;7(1):1901728. doi: 10.1002/advs.201901728

Figure 2.

Figure 2

Knockdown of IL1R2 attenuated the malignancy of BC cells. A) Representative flow cytometry analysis results for the BTIC population in IL1R2‐knockdown SUM149 cells. B) Statistical results of the BTIC population analyzed by flow cytometry assays in SUM149 and HCC1937 cells (*, p < 0.05 vs the shSCR control). C) IL1R2 knockdown inhibited cell proliferation ability in the soft agar colony formation assay (*, p < 0.05; **, p < 0.01 vs the shSCR control). D) IL1R2 knockdown inhibited cell migration ability in the wound‐healing assay (**, p < 0.01 vs the shSCR control). E) IL1R2 knockdown inhibited cell self‐renewal ability of SUM149 cells in the mammosphere formation assay (**, p < 0.01 vs the shSCR control) (representative images were shown). Original magnification, 40×). F) IL1R2 knockdown in SUM149 cells inhibited xenograft tumor growth in nude female mice (*, p < 0.05; **, p < 0.01 vs the shSCR control). G) The flow cytometry analysis results of the BTIC population in xenograft tumors (*, p < 0.05 vs the shSCR control). H) The stem cell frequency in SUM149 xenograft tumors was calculated by the limited dilution assay.