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. 2019 Nov 13;7(1):1901412. doi: 10.1002/advs.201901412

Figure 5.

Figure 5

PLLA nanofibrous substrates activated the mitogen‐activated protein kinase (MAPK) signaling pathway by downregulating miR‐193a‐3p. a,b) miRNA–mRNA integrated analysis of the flat (OS+) (a) random groups (b). c) Significantly enriched pathways for the 650 putatively upregulated genes in (a) (p < 0.001). d) Significantly enriched pathways for the 257 putatively upregulated genes in (b) (p < 0.05). e–g) mRNA and h) protein levels of MAPK kinases in bone marrow stem cells (BMSCs) treated with agomir, antagomir, or their scrambled controls. Results are means ± SEM (n = 3). Samples were subjected to one‐way ANOVA with Tukey's post hoc test (*p < 0.05, **p < 0.01).