Table 2.

Selected associations between relative abundance of bacteria and seroresponse to RV5 vaccination*

Bacteria	Responders, MRA (SD)	Nonresponders, MRA (SD)	Wilcoxon–Mann–Whitney 2-sided P-value	FDR-corrected P-value
Phylum
Proteobacteria	0.040022 (0.032079)	0.092023 (0.108095)	0.06	0.31
Fusobacteria	0.004647 (0.021920)	0.000009 (0.000026)	0.06	0.31
Actinobacteria	0.174979 (0.167543)	0.141047 (0.156533)	0.31	0.85
Thermi	0.000009 (0.000031)	0.000012 (0.000053)	0.34	0.85
Tenericutes	0.000001 (0.000007)	0.000000 (0.000000)	0.56	0.92
TM7	0.000113 (0.000405)	0.000106 (0.000308)	0.63	0.92
Cyanobacteria	0.000003 (0.000010)	0.000004 (0.000013)	0.67	0.92
Verrucomicrobia	0.000077 (0.000318)	0.002436 (0.006906)	0.83	0.92
Firmicutes	0.502032 (0.239870)	0.482842 (0.268181)	0.83	0.92
Bacteroidetes	0.277153 (0.244999)	0.280203 (0.273953)	0.97	0.97
Genera
Eggerthella	0.000139 (0.000312)	0.000007 (0.000020)	0.02	1.00
Enterobacteriaceae†	0.015892 (0.020168)	0.036539 (0.045746)	0.03	1.00
Megamonas	0.011465 (0.057317)	0.000794 (0.003480)	0.05	1.00
Roseburia	0.000012 (0.000029)	0.000000 (0.000000)	0.06	1.00
Fusobacterium	0.004644 (0.021921)	0.000008 (0.000026)	0.06	1.00
Parabacteroides	0.017832 (0.036384)	0.004744 (0.013960)	0.07	1.00
Erysipelotrichaceae†	0.062857 (0.118074)	0.009887 (0.017497)	0.09	1.00
Xanthomonadaceae†	0.000036 (0.000128)	0.000002 (0.000005)	0.09	1.00
Sutterella	0.005797 (0.018688)	0.015933 (0.031513)	0.10	1.00

FDR = false discovery rate; MRA = mean relative abundance.

* Includes Wilcoxon–Mann–Whitney results for all phyla but only selected genera that had a P-value of < 0.10 after applying a FDR correction.

† The 16s rRNA amplicon sequencing approach used could not distinguish below the family level for Enterobacteriaceae, Erysipelotrichaceae, and Xanthomonadaceae.