Figure 1.

Flowchart of the study on Tonate virus infection in French Guiana, 2003–2016. MAYV = Mayaro Virus; TONV = Tonate Virus. ¹Nine positive IgMs obtained 0–1 day after the onset of the symptoms; three with decreasing titer ratio between two successive samples, three with very slightly positive serology (negative ratio < 2, positive ratio > 3, and gray area between 2 and 3), and one with no information on the start date of clinical signs. ²Alphavirus cross-reactivity = reactivity to TONV and/or CHIKV and/or MAYV. ³Three deliveries, one pregnancy finding, one oral cancer, one atrial fibrillation, one renal colic, one myocardial infarction, one lung edema, one palpitation, two rheumatoid arthritis, one cirrhosis, one vaso-occlusive crisis, one atrial fibrillation, one pregnancy vomiting and one other. ⁴Thirty malaria attacks (19 P. vivax, nine P. falciparum, one coinfection, and two without species), 31 other arboviruses (17 chikungunya, 13 dengue, and one Zika), six angina (including three Epstein–Barr virus), 15 lung infections, five pyelonephritis, four leptospirosis, four Q fever, and 29 other infectious diagnoses. ⁵One persistent asthenia without fever and one infectious picture in a person with connective tissue disease with interstitial lung disease.