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. 2019 Dec 17;21(2):867–875. doi: 10.3892/mmr.2019.10889

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Copyright: © Geng et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 1. — Effects of SHOC2 knockdown on proliferation, cell cycle progression and apoptosis of breast cancer cells. (A) Protein expression of SHOC2 after knockdown in MCF-7 and MDA-MB-231 breast cancer cells. MTT assay results of (B) MCF-7 and (C) MDA-MB-231 breast cancer cells. Cell cycle distribution of (D) MCF-7 and (E) MDA-MB-231 breast cancer cells, as determined by flow cytometry. Cell apoptosis analyzed using flow cytometry and Annexin V staining of (F) MCF-7 and (G) MDA-MB-231 breast cancer cells. For apoptosis analysis, the right quadrants were assessed. *P<0.05, ***P<0.001 vs. shCtrl. Ctrl, control; OD, optical density; SHOC2, SHOC2 leucine rich repeat scaffold protein; sh, short hairpin RNA.