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. 2019 Dec 17;21(2):867–875. doi: 10.3892/mmr.2019.10889

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Copyright: © Geng et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 2. — Effects of SHOC2 knockdown on the expression of Ras signaling pathway and apoptosis-related proteins in breast cancer cells. (A) Protein expression of Bcl-2, Bax and cleaved-PARP following SHOC2 knockdown in MCF-7 and MDA-MB-231 breast cancer cells. (B) Protein expression of AKT, p-AKT, ERK and p-ERK following SHOC2 knockdown in MCF-7 and MDA-MB-231 breast cancer cells. ***P<0.001 vs. shCtrl. Ctrl, control; PARP, poly (ADP-ribose) polymerase; p, phosphorylated; SHOC2, SHOC2 leucine rich repeat scaffold protein; sh, short hairpin RNA.