Table II.

Univariate and multivariate survival analyses of various factors in patients with breast cancer.

	Univariate			Multivariate
Characteristics	HR	95% CI	P-value	HR	95% CI	P-value
Age
≤40 years	1
>40 years	0.765	0.387–1.510	0.439
Tumor size
≤2 cm	1			1
>2 cm	2.280	1.121–4.635	0.023	1.077	0.507–2.288	0.847
Histopathological grade
I	1
II	1.019	0.462–2.244	0.964
III	1.102	0.726–1.674	0.648
ER
−	1			1
+	0.444	0.231–0.854	0.015	0.415	0.212–0.812	0.010
PR
−	1
+	0.703	0.356–1.387	0.309
HER2
−	1
+	1.087	0.560–2.108	0.805
Lymph node status
−	1			1
+	4.984	2.561–9.700	<0.01	5.262	2.590–10.691	<0.001
SHOC2 expression
Low				1
High	3.428	1.212–9.697	0.020	5.440	1.865–15.863	<0.001

ER, estrogen receptor; HER2, human epidermal growth factor receptor 2; PR, progesterone receptor; SHOC2, SHOC2 leucine rich repeat scaffold protein.