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. 2020 Jan 8;27:22. doi: 10.1186/s12929-019-0607-9

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© The Author(s). 2020

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — The structure of the EV-A71 genome. The 5′ UTR of EV-A71 contains six stem-loop RNA domains (I-VI). Domain I functions in negative-strand RNA synthesis, whereas domains II–VI form an IRES element. The ORF encodes a polyprotein, which is cleaved into 11 viral proteins by viral and/or cellular proteases