Table V.
Validation of the top ten hypermethylation-low expression genes in TCGA database.
| Gene | Methylation status | P-value | Expression status | P-value |
|---|---|---|---|---|
| CREBBP | Hypermethylation | 1.06×10−123 | Downregulated | 1.64×10−1 |
| SMAD3 | Hypermethylation | 6.27×10−121 | Downregulated | 1.34×10−10 |
| MCC | Hypermethylation | 2.39×10−126 | Downregulated | 2.13×10−20 |
| VIM | Hypermethylation | 1.11×10−134 | Downregulated | 1.26×10−5 |
| ATXN1 | Hypermethylation | 3.54×10−134 | Downregulated | 2.13×10−4 |
| CAV1 | Hypermethylation | 1.31×10−133 | Downregulated | 7.54×10−26 |
| FLNA | Hypermethylation | 8.64×10−126 | Downregulated | 1.12×10−15 |
| MAP3K14 | Hypermethylation | 2.39×10−123 | Downregulated | 1.79×10−7 |
| PRKCB | Hypermethylation | 1.24×10−133 | Downregulated | 6.56×10−20 |
| FHL2 | Hypermethylation | 1.74×10−123 | Downregulated | 1.71×10−12 |
TCGA, The Cancer Genome Atlas.