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. 2019 Dec 4;21(2):583–588. doi: 10.3892/mmr.2019.10857

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Copyright: © Duan et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 4. — Proposed mechanism of action of DAPT in the cisplatin-induced Notch signaling pathway in STZ-induced diabetic rats. (A) Western blotting demonstrated that DAPT treatment induced higher level of IL-10, TNF-α and HIF1α expressions. (B) Cisplatin triggers the Notch signaling pathway to increase its levels of oxidation and HIF expression, which induces further damage of the renal tissues. Blockage of Notch using DAPT mitigates renal tissue damage in STZ-induced diabetic rats. DAPT, N-[N-(3,5-difluorophenacetyl)-L-alanyl]-S-phenylglycine t-butyl ester; STZ, streptozocin; IL, interleukin; TNF, tumor necrosis factor; HIF, hypoxia-inducible factor.