Fig. 2.

Bayesian phylogenetic tree of 278 Moldovan Mtb genomes with heat map of drug resistance SNPs. The Bayesian phylogeny was calculated using 13,321 genomic SNPs. SNPs at PE/PPE protein loci were not included in this calculation. Thick branches have posterior probabilities greater than 0.95. Tree tip branch colors represent drug resistance testing results for each sample, with the result status color indicated in the legend. Spoligotype lineages are labeled at the most ancestral branch for groups belonging to those lineages. The two MANU2 samples did not group together. The heat map shows the presence or absence of drug-resistance SNPs that were determined to be significantly associated with resistance to specific drugs by ReSeqTB. Black cells represent the presence of a DR SNP. Grey cells represent ambiguous calls for a DR SNP. Cells with a wavy fill did not have reliable nucleotide calls at the DR loci