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. 2020 Jan 7;21:8. doi: 10.1186/s12931-019-1267-8

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© The Author(s). 2020

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — Flow chart of the review and meta-analysis. Randomized controlled trials published as full articles, enrolling preterm neonates (gestational age < 37 weeks) with clinical and/or radiological evidence of RDS, comparing porcine and bovine surfactants (irrespective of their preparation method) and reporting at least one extra-pulmonary outcomes were included in the systematic review. The excluded studies were two full text duplicates reporting the same data with major methodological flaws and one conference abstract which did not respect the eligibility criteria. Details of excluded studies are available in [7]