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. 2020 Jan 7;10:4. doi: 10.1186/s13578-019-0371-2

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 6 — miR-135a-5p modulated ox-LDL-induced injury of HUVECs via targeting ROCK1 and ROCK2. ox-LDL-induced HUVECs were transfected with miR-NC mimics, miR-135a-5p mimics, miR-135a-5p mimics + Vector, miR-135a-5p mimics + ROCK1, or miR-135a-5p mimics + ROCK2. a, b The expression of ROCK1 or ROCK2 was examined by RT-qPCR. c Cell viability was measured by CCK-8 assay. d Cell apoptosis was detected by flow cytometry. e The protein expression of Bax and Bcl-2 was tested by western blot assay. f Caspase-3 activity was evaluated by using commercially-available kit. g, h The secretion of IL-6 and TNF-α were detected by ELISA assay. i, j The production of ROS and MDA were examined using commercially-available kits. **P < 0.01; ^#P < 0.05 and ^##P < 0.01