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. 2020 Jan 7;12:6. doi: 10.1186/s13148-019-0805-z

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© The Author(s). 2020

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 3 — Change in BMI (kg/m²) per % methylation change. From left to right: (i) reference EU vs IA data, (ii) IA vs. PURE-SA-NW data and (iii) EU vs. PURE-SA-NW data. Model used for PURE-SA-NW EWAS: BMI ~ methylation + age + smoking status + alcohol consumption + physical activity + cell counts + surrogate variables. Reference data: Wahl et al. (2017). Green data points represent CpGs where the 95% CIs for effect size estimates in each sample group overlap. Yellow data points represent CpGs where the 95% CIs for effect size estimates in each sample group do not overlap. Red data points represent the comparison of effect sizes within the reference cohorts. Black dashed line: line of equality. Blue dashed line: regression line