Table 2.
Acute Adverse Events.
| Adverse Event | Chemoradiotherapy (N = 346) | Chemotherapy Only (N = 361) | P Value* | ||
|---|---|---|---|---|---|
| Any Grade | Grade 3–5 | Any Grade | Grade 3–5 | ||
| percent of patients | |||||
| Constitutional symptom | 87 | 6 | 80 | 2 | 0.004 |
| Fatigue | 85 | 5 | 75 | 2 | <0.001 |
| Cardiac event | 16 | 3 | 19 | 4 | 0.71 |
| Endocrine event | 11 | 1 | 11 | 0 | 0.46 |
| Gastrointestinal event | 90 | 13 | 79 | 4 | <0.001 |
| Renal or genitourinary event | 33 | 2 | 11 | 1 | <0.001 |
| Blood or bone marrow event | 96 | 40 | 90 | 52 | 0.01 |
| Infection | 23 | 4 | 20 | 5 | 0.18 |
| Lymphatic event | 17 | <1 | 16 | <1 | 0.74 |
| Musculoskeletal event | 20 | 3 | 13 | 1 | 0.01 |
| Metabolic or laboratory event | 48 | 15 | 44 | 9 | 0.02 |
| Neurologic event | 76 | 7 | 80 | 5 | 0.99 |
| Pulmonary event | 31 | 2 | 26 | 1 | 0.83 |
| Pain | 70 | 8 | 68 | 5 | 0.04 |
*
P values for the between-group comparison of the maximum grade of adverse events were calculated with a Kruskal-Wallis test corrected for ties.