Table 2.

Studies related to GLUT1 application in assessing prognosis of carcinomas

Study	Results
Martin Kunkel et al. 2003, conducted a immunohistochemical study on oral squamous cell carcinomas (OSCC)	Increase GLUT1 is associated with poor prognosis of patients. This increase in GLUT1 bypasses apoptosis causing increased survival of cells leading to aggressiveness of the lesion.
Martin Kunkel et al. 2007, conducted a immunohistochemical study oral squamous cell carcinoma and compared it with the resistance to radiotherapy	Increase in the expression of GLUT1 is associated with increased resistance to radiotherapy which cause poor prognosis and reduced survival rate. They have concluded that GLUT1 can be used as a marker to assess radioresistance prior to start of radiotherapy
Makoto Endo et al. 2007, conducted a immunohistochemical study on bone and soft tissue sarcomas	Increased expression of GLUT1 has been correlated with poor prognosis of the patient and it has been correlated with the results of other prognostic markers. The authors have suggested that this can be used to assess high risk patients prior to start of therapy.
Shinichi Ohba et al. 2010, conducted a immunohistochemical study on oral squamous cell carcinoma and compared the GLUT1 expression in invasive front of tumor with prognosis	Increased expression of GLUT1 has been noted in the lesions with invasive front at a depth more than 4mm which was correlated with increased aggressiveness, resistance to radio and chemo therapy, poor prognosis and overall survival rate.
Jyotsna M Harshini et al. 2014, conducted a immunohistochemical study on oral squamous cell carcinoma	GLUT1 expression has correlated with the staging, grading and prognosis of the patient and they suggested that increased GLUT1 can be regarded as an early event in development of OSCC