Table 3.
ROC curve analysis of PET parameters using a SUV threshold of 2.5 against DFS
| Parameter | Optimal Cut-off | Sensitivity (%) | 1-Specificity (%) | AUC | 95% CI (upper and lower) | P value |
|---|---|---|---|---|---|---|
| PET 2 | ||||||
| SUVmax | 10.35 | 87.5 | 37.5 | 0.698 | 0.509–0.887 | 0.098 |
| SUVmean | 4.7 | 75 | 25 | 0.706 | 0.497–0.914 | 0.086 |
| TLG | 99.75 | 75 | 37.5 | 0.594 | 0.366–0.821 | 0.433 |
| MTV | 22.1 | 62.5 | 37.5 | 0.536 | 0.294–0.779 | 0.761 |
| PET 3 | ||||||
| SUVmax | 5.65 | 75 | 37.5 | 0.643 | 0.439–0.848 | 0.231 |
| SUVmean | 3.35 | 87.5 | 58.3 | 0.633 | 0.423–0.842 | 0.267 |
| TLG | 34.525 | 62.5 | 29.2 | 0.651 | 0.434–0.868 | 0.207 |
| MTV | 8.95 | 62.5 | 29.2 | 0.646 | 0.427–0.864 | 0.223 |
| PET 1–2 absolute reduction | ||||||
| SUVmax | 3.6 | 62.5 | 20.8 | 0.641 | 0.417–0.864 | 0.240 |
| SUVmean | 1.3 | 62.5 | 29.2 | 0.643 | 0.410–0.876 | 0.231 |
| TLG | 195.72 | 75 | 33.3 | 0.667 | 0.467–0.866 | 0.164 |
| MTV | 10.25 | 75 | 16.7 | 0.698 | 0.486–0.910 | 0.098 |
| PET 1–2 relative reduction (%) | ||||||
| SUVmax | 25.185 | 62.5 | 29.2 | 0.693 | 0.502–0.883 | 0.107 |
| SUVmean | 25.5 | 62.5 | 41.7 | 0.648 | 0.430–0.866 | 0.215 |
| TLG | 46 | 62.5 | 25 | 0.703 | 0.509–0.897 | 0.09 |
| MTV | 30.5 | 62.5 | 20.8 | 0.753 | 0.574–0.931 | 0.035 |
| PET 1–3 absolute reduction | ||||||
| SUVmax | 10.15 | 75 | 33.3 | 0.635 | 0.400–0.871 | 0.258 |
| SUVmean | 3.35 | 75 | 50 | 0.635 | 0.377–0.873 | 0.296 |
| TLG | 175.66 | 62.5 | 25 | 0.646 | 0.441–0.851 | 0.223 |
| MTV | 24.75 | 75 | 25 | 0.750 | 0.559–0.941 | 0.037 |
| PET 1–3 relative reduction (%) | ||||||
| SUVmax | 69 | 75 | 41.7 | 0.706 | 0.517–0.895 | 0.086 |
| SUVmean | 42.5 | 62.5 | 33.3 | 0.674 | 0.476–0.873 | 0.145 |
| TLG | 94 | 75 | 33.3 | 0.703 | 0.485–0.922 | 0.09 |
| MTV | 87 | 75 | 29.2 | 0.721 | 0.497–0.945 | 0.064 |
AUC, area under curve; CI, confidence interval; MTV, metabolic tumour volume; PET, positron emission tomography; SUV, standardized uptake value; TLG, total lesion glycolysis.