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. Author manuscript; available in PMC: 2020 Dec 23.
Published in final edited form as: Anal Biochem. 2019 Dec 24;591:113560. doi: 10.1016/j.ab.2019.113560

Figure 3. Redox regulation of TG2.

Figure 3.

TG2 cofactors TRX and ERp57 reversibly regulate TG2 in a redox-dependent manner, and act as “on” and “off” switches for the active enzyme (green). As TG2 is natively inactive (gray), TRX is able to reduce the vicinal disulfide bond between C370-C371 to activate TG2, and ERp57 can oxidize the disulfide between C230 and C370 to catalytically inactivate the enzyme.