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. Author manuscript; available in PMC: 2020 Jan 8.
Published in final edited form as: Immunity. 2018 Mar 20;48(3):417–433. doi: 10.1016/j.immuni.2018.03.007

Figure 1: Three discriminatory functions of the immune system, antigenicity, adjuvanticity, and feedback regulation, are critical for promoting anti-tumor immunity.

Figure 1:

T cells recognize tumor associated antigens (TAA), which can be generated by mutations in tumor cells, when presented in the context of class I MHC. The presence of non-self antigens must be accompanied by danger signaling to activate the innate immune system, promote dendritic cell (DC) maturation, and T cell activation. Normal homeostatic feedback mechanisms then curb the immune response to limit immunopathology after clearance of pathogens.