Table 1.

Strategies to restore PRR signaling

Target	Examples under clinical investigation ± ICB	References
PRR activation	Chemotherapy	Galluzzi et al, 2015
	Radiation	Shabason and Minn, 2017
	HER2-directed antibody	Park et al, 2010, Stagg et al, 2011
	PRR agonists	Fu et al, 2015, Corrales et al, 2015, Charlebois et al, 2017, Kranz et al 2016, Shekarian et al, 2017
	Oncolytic viruses	Ribas et al, 2017
Endogenous retroviruses	DNMT inhibitors	Chiappinelli et al, 2015; Roulois et al, 2015 Topper et al, 2017
	HDAC inhibitors
	CDK4/6 inhibitors	Goel et al, 2017, Zhang et al, 2018
Costimulatory agonist	CD40 agonist	Byrne and Vonderheide, 2016