Table 4:
Impact of serum containing media and the effect of DEX on the functional properties of MSC-laden constructs (mean ± SD; n = 4/group).
4w | 8w | ||||||
---|---|---|---|---|---|---|---|
Serum | CM+ | Serum | CM+ | ||||
TGF-/DEX+ | TGF+/DEX- | TGF+/DEX+ | TGF+/DEX- | TGF+/DEX+ | |||
EY (kPa) | 0 | 0 | 0 | 231 ± 26 | 0 | 21 ± 10 | 426 ± 128 |
|G*| (kPa) | 95 ± 21 | 0 | 123 ± 33 | 2208 ± 162 | 284 ± 63 | 916 ± 247 | 3330 ± 603 |
Diameter (mm) | 3.0 ± 0.0 | 1 ± 0.0 | 2.4 ± 0.1 | 4 ± 0.0 | 3.8 ± 0.0 | 3.9 ± 0.1 | 4.0 ± 0.0 |
GAG (%WW) | 0.2 ± 0.0 | 0.8 ± 0.0 | 0.6 ± 0.4 | 2.9 ± 0.1 | 0.7 ± 0.1 | 1.9 ± 0.4 | 4.6 ± 0.7 |
GAG (μg/const) | 15.4 ±3.7 | 11.6 ± 2.5 | 26.1 ± 1.6 | 795 ± 16.3 | 193 ± 35 | 524 ± 92 | 1247 ± 209 |
COL (%WW) | 0.8 ± 0.9 | 3.2 ± 1.7 | 2.0 ± 1.5 | 2.1 ± 0.6 | 2.4 ± 0.6 | 2.4 ± 0.4 | 2.8 ± 0.6 |
COL (μg/const) | 48 ± 37 | 45 ± 20 | 86 ± 38 | 581 ± 193 | 654 ± 184 | 647 ± 95 | 757 ± 154 |