Table 1.
Comparison of anthropometry, maturity, plasma miR-145 level and serum bone turnover markers at first visit between severe and non-severe AIS (N = 120).
| Cobb angle > 40° (N = 27) | Cobb angle ≤ 40° (N = 93) | p-value | |
|---|---|---|---|
| Age (years) b | 12.48 (12.06, 13.46) | 13.08 (12.12, 13.67) | 0.291 |
| Initial maximum Cobb angle(o) b | 30 (28, 32) | 21 (18, 26) | <0.001 |
| Latest maximum Cobb angle(o) b | 42 (39, 49) | 27 (22, 31) | <0.001 |
| Anthropometry | |||
| Body weight (kg) a | 38.3 ± 5.0 | 41.7 ± 6.1 | 0.009 |
| Body height (cm) a | 152.0 ± 7.2 | 154.0 ± 6.4 | 0.166 |
| Arm span (cm) a | 152.5 ± 7.5 | 153.2 ± 7.4 | 0.660 |
| Maturity | |||
| Year since menarche (years) b | 0.69 (0.23, 1.20) | 0.84 (0.39, 1.19) | 0.490 |
| Menarche before first visit c,d | 12 (44.4%) | 67 (72.0%) | 0.008 |
| Risser sign b,e | 0.002 | ||
| 0 (17) | 0 (26) | ||
| 1 (1) | 1 (14) | ||
| 2 (5) | 2 (15) | ||
| 3 (3) | 3 (16) | ||
| 4 (1) | 4 (22) | ||
| 5 (0) | 5 (0) | ||
| Plasma micro-RNA level | |||
| ln (miR-145) a,f | −5.7 ± 1.23 | −4.95 ± 1.84 | 0.018 |
| Serum bone turnover markers2 | |||
| ln (CTx) a,g | 7.02 ± 0.56 | 6.85 ± 0.55 | 0.179 |
| ln (P1NP) a,g | 6.47 ± 0.52 | 6.19 ± 0.59 | 0.033 |
Latest maximum Cobb angle is measured at latest clinical visit after completing follow-up. Other parameters are measured at patients’ first clinical visit.
Normally distributed data is presented as Mean ± SD and Independent sample t-test was used.
Data are not normally distributed and presented as median (lower quartile, upper quartile) and Mann-Whitney U test is used.
Chi-squared test is used.
Menarche status, 1 = onset of menarche is earlier than the first clinical visit and 0 = premenarche at first clinical visit.
Risser sign is presented as frequency of each level of Risser score.
The value for “the plasma level of miR-145″ is the fold change relative to the level of the housekeeping reference miR-16. A log of the plasma level of miR-145 with the base e is calculated.
The level of CTX P1NP in the serum is represented as µg/L. A log of CTX/P1NP concentration with the base e is calculated and used.