Figure 6.

miR-10b Promotes hESC-CM Proliferation by Inhibiting the Hippo Pathway

(A) Immunofluorescence images of YAP (red) subcellular localization in hESC-CMs transfected with si-NC/si-LATS1 and NC/miR-10b mimics. Nuclei were stained with DAPI (blue). (B) Quantification of YAP subcellular localization. C, cytoplasm; N, nucleus. More than 100 cells were randomly selected in each calculation. Statistical significance was calculated using Student’s t test for paired samples. Data are shown as the means ± SEM. *p < 0.05, **p < 0.01. (C) Proposed model of miR-10b promotion of hESC-CM proliferation through inhibiting the Hippo pathway.