Table 2.
Summary of univariate and multivariate regression analyses predicting urinary CN-1 concentrations in T2DM and nondiabetic CKD patients (n = 104).
| Univariate analysis | Multivariate analysis | |||||||
|---|---|---|---|---|---|---|---|---|
| Variable | Coefficient (β) | 95% CI | p value | Coefficient (β) | 95% CI | p value | ||
| Age (years) | -0.007 | -0.014 | 0.001 | 0.092 | 0.002 | -0.005 | 0.010 | 0.56 |
| Male sex | 0.17 | -0.08 | 0.42 | 0.18 | 0.14 | -0.044 | 0.33 | 0.13 |
| Nondiabetic kidney disease | 0.075 | -0.208 | 0.36 | 0.60 | — | — | — | |
| On renal replacement therapy | -0.095 | -0.34 | 0.15 | 0.43 | — | — | — | |
| CNDP1 (CTG)5 homozygosity | -0.500 | -0.43 | 0.08 | 0.17 | -0.033 | -0.23 | 0.16 | 0.74 |
| Log (serum CN-1) | 0.195 | -0.012 | 0.40 | 0.065 | 0.21 | 0.053 | 0.36 | 0.009 |
| Log (ACR) | 0.47 | 0.37 | 0.57 | <0.0001 | 0.48 | 0.37 | 0.60 | <0.0001 |
| eGFR (ml/min/1.73 m2) | -0.009 | -0.009 | -0.0004 | 0.032 | 0.001 | -0.003 | 0.005 | 0.66 |
Univariate and multivariate regression models with log-transformed urinary CN-1 as the dependent variable. Goodness of fit of the multivariate regression full model: adjusted R2 = 0.47; p < 0.0001.