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. 2019 Dec 25;2019:9612125. doi: 10.1155/2019/9612125

Figure 5.

Figure 5

Knockdown of TRIM11 decreased the tumorigenicity of OS cells in vivo. (a) Tumors were removed from nude mice that were injected with siNC or siTRIM11-1 transfected cells. (b, c) Knockdown of TRIM11 significantly suppressed tumor growth in vivo.∗∗∗p < 0.001 vs siNC. (d) Cell apoptosis was upregulated in siTRIM11-1 tumors than in siNC tumors. ∗∗∗p < 0.001 vs siNC. (e) Immunofluorescence detection assay was used to examine the level of TRIM11, DUSP6, and ERK1/2 in siNC and siTRIM11-1 tumors, respectively. Magnification, 200x. (f) Western blot was used to examine the protein content of TRIM11, DUSP6, p-ERK1/2, and ERK1/2 in siNC or siTRIM11-1 tumors. ∗∗∗p < 0.001 vs siNC.