Table 2.
A list of predicted metabolic biomarkers involved in the pathogenesis of CCM and RV and LV dilations in the murine models of chronic Chagas disease (arrows indicate decrease or increase).
| Amino acids | CCM | RV | LV |
|---|---|---|---|
| Citrulline↓ Glutamine↓ |
Arginine↑ Asparagine↑ |
||
| Amino derivative | |||
| Alpha-AAA↑ PEA↓ Spermidine↓ |
Sarcosine↑ | Sarcosine↓ | |
| Carnitines | |||
| C9↓ C6:1↓ C14:1↓ C6 (C4:1-DC)↑ |
C16:OH↑ C16↓ C5-OH (C3-DC-M)↓ |
C12↑ C16↑ C16:1↑ C18:1↑ C18:1OH↑ C5-OH (C3-DC-M)↑ |
|
| Sphingolipids | |||
| SM(OH)C14:1↓ SM C16:1↓ |
SM C20:2↑ | SM C20:2↓ | |
| lysoPC | |||
| lysoPC a C18:1↓ lysoPC a C18:2↓ lysoPC a C20:3↓ lysoPC a C28:1↓ |
lysoPC a C26:0↑ lysoPC a C26:1↑ |
||
| PC-aa/ae | |||
| PC-aa-C36:3↓ PC-aa-C38↓ PC-aa-C38:3↓ PC-ae-C36:2↓ PC-ae-C38:3↓ PC-ae-C38:4↓ PC-ae-C40:4↓ PC-ae-C40:6↓ PC-ae-C42↓ |
PC-ae-C38:2↓ |