Table 3.
Results from the SBM differences between patients with bipolar disorder and healthy controls analyses. Report of significant regions where patients showed reduced cortical volume and thickness compared to healthy controls, at p < 0.05, cluster-based corrected for multiple comparisons. Structures are labeled using the Deskian-Killiany atlas included in FreeSurfer and they are ordered by overlapping percentage. The overlapping percentage of each brain region is calculated as 100% x NumVcluster/NumVregion, where NumVcluster is the number of vertices of the cluster within a region and NumVregion is the total number of vertices of that region.
| Metrics | Main peak | Cluster | |||
|---|---|---|---|---|---|
| MNI Coordinates (x,y,z) | p-value | Number of vertices | Cluster p-value | Main involved structures (ordered by overlapping percentage) | |
| Cortical volume | |||||
| Right Brain | |||||
| Inferior parietal cortex | (36, −46, 36) | <1e−8 | 3994 | 8e−4 | Inferior parietal (29), Superior parietal (9), Supramarginal (3) |
| Middle temporal cortex | (48, −27, −11) | <1e−4 | 4127 | 6e−4 | Transverse temporal (90), Superior temporal (26), Middle temporal (22), Insula (10) |
| Superior frontal cortex | (9, 56, 30) | <1e−3 | 1244 | 0.04 | Superior frontal (10) |
| Lateral orbitofrontal cortex | (17, 41, −18) | <1e−3 | 3219 | 8e−4 | Lateral orbitofrontal (64), Medial orbitofrontal (9), Frontal pole (5) |
| Left Brain | |||||
| Supramarginal gyrus | (−55, −30,35) | <1e−5 | 2554 | 0.01 | Supramarginal (24), Postcentral (5) |
| Middle temporal cortex | (−64, −26, −16) | <1e−4 | 3381 | 4e−4 | Middle temporal (55), Bankssts (14), Superior temporal (6), Inferior temporal (5) |
| Inferior parietal cortex | (−32, −58, 37) | <1e−4 | 2576 | 0.013 | Inferior parietal (17), Superior parietal (9), Supramarginal (3) |
| Cortical Thickness | |||||
| Right Brain | |||||
| Transverse temporal cortex | (41, −26, 3) | <1e−4 | 16257 | 2e−4 | Transverse temporal (100), Frontal pole (75), Superior temporal (63), Parsorbitalis 63), Insula (60), Parstriangularis (51) |
| Inferior parietal cortex | (48, −47, 38) | <1e−4 | 7193 | 2e−4 | Supramarginal (39), Inferior parietal (32), Bankssts (26) |
| Lateral occipital cortex | (42, −77, −5) | <1e−3 | 1426 | 0.02 | Lateral occipital (22), Inferior temporal (3) |
| Caudal middle frontal cortex | (30, 14, 47) | <1e−3 | 2478 | 5e−3 | Caudal middle frontal (43), Superior frontal (5) |
| Lingual gyrus | (14, −61, 2) | <1e−3 | 1639 | 0.036 | Lingual (32), Pericalcarine (11), Parahippocampal (7) |
| Left Brain | |||||
| Parsopercularis | (−42, 10, 8) | <1e−5 | 21876 | 2e−4 | Transverse temporal (100), Parsopercularis (88), Parsorbitalis (65), Parstriangularis (63), Superior temporal (54), Middle temporal (49), Frontal pole (45), Bankssts (38), Insula (37) |
| Fusiform gyrus | (−32, −45, −20) | <1e−3 | 1724 | 0.02 | Fusiform (35) |
| Supramarginal gyrus | (−40, −51, 35) | <1e−3 | 3350 | 5e−3 | Inferior parietal (13), Superior parietal (12), Supramarginal (12) |