Table 4.
Results from the SBM differences between patients with schizophrenia and bipolar disorder analyses. Report of significant regions where patients showed reduced cortical volume, thickness, surface area and gyrification index compared to healthy controls, at p < 0.05, cluster-based corrected for multiple comparisons. Structures are labeled using the Deskian-Killiany atlas included in FreeSurfer and they are ordered by overlapping percentage. The overlapping percentage of each brain region is calculated as 100% x NumVcluster/NumVregion, where NumVcluster is the number of vertices of the cluster within a region and NumVregion is the total number of vertices of that region.
| Metrics | Main peak | Cluster | |||
|---|---|---|---|---|---|
| MNI Coordinates (x,y,z) | p-value | Number of vertices | Cluster p-value | Main involved structures (ordered by overlapping percentage) | |
| Cortical volume | |||||
| Right Brain | |||||
| Insula | (36, 7, −11) | <1e−5 | 5931 | 2e−4 | Insula (75), Parsopercularis (26), Temporal pole (15) |
| Lingual gyrus | (26, −57, 7) | <1e−5 | 3839 | 8e−4 | Isthmus cingulate (50), Lingual (24), Precuneus (18), Pericalcarine (14) |
| Superior frontal cortex | (78, 34, 45) | <1e−4 | 3632 | 2e−4 | Superior frontal (31) |
| Lateral occipital cortex | (17, −94, 15) | <1e−4 | 3072 | 2e−4 | Lateral occipital (44), Cuneus (5) |
| Left Brain | |||||
| Insula | (−36, −1, −6) | 4398 | 8e−4 | Insula (65), Parsopercularis (22), Parstriangularis (4) | |
| Superior frontal cortex | (−15, 42, 14) | 2041 | 0.0054 | Rostral anterior cingulate(24), Superior frontal (14) | |
| Lateral occipital cortex | (−25, −94, −16) | 3186 | 2e−4 | Lateral occipital (50) | |
| Cortical Thickness | |||||
| Right Brain | |||||
| Posterior cingulate cortex | (4, −4, 30) | <1e−4 | 2922 | 0.015 | Posterior cingulate (55), Caudal anterior cingulate (54) |
| Left Brain | |||||
| Insula | (−36, −9, −2) | 1e−5 | 3900 | 0.00240 | Insula (51), Superior temporal (17) |
| Fusiform gyrus | (−41, −46, −15) | <1e−3 | 2616 | 0.0028 | Inferior temporal (30), Fusiform (24), Lateral occipital (2) |
| Cortical Surface Area | |||||
| Right Brain | |||||
| Lingual gyrus | (24, −55, 7) | <1e−3 | 2183 | 0.026 | Isthmus cingulate (37), Lingual (21), Precuneus (6) |
| Lateral occipital cortex | (18, −94, 16) | <1e−3 | 1862 | <5e−3 | Lateral occipital (27), Cuneus (8) |
| Left Brain | |||||
| Lateral occipital cortex | (−28, −95, −14) | <1e−3 | 1592 | < 5e−3 | Lateral occipital (25) |
| Gyrification index | |||||
| Right Brain | |||||
| Cuneus | (9, −70, 19) | 1e−3 | 3407 | 8e−4 | Cuneus (67), Pericalcarine (53), Precuneus (15), Lingual (4) |
| Left Brain | |||||
| Supramarginal gyrus | (−56, −37, 32) | <1e−4 | 9049 | 2e−4 | Supramarginal (68), Postcentral (26), Superior temporal (6) |
| Cuneus | (−13, −69, 15) | <1e−3 | 9587 | 2e−4 | Pericalcarine (79), Precuneus (67), Cuneus (64), Lingual (45), Isthmus cingulate (11) |