Table 2.
Diagnostic performance of APTw signals from nine regions of interest (ROIs) in predicting aMCI.
| ROIs | AUC (95% CI) | Sensitivity (95% CI) (%) | Specificity (95% CI) (%) | PPV (95% CI) (%) | NPV (95% CI) (%) | Cutoff Value (%) |
|---|---|---|---|---|---|---|
| Hippocampus | 0.70 (0.51–0.83) | 66.7 (41.0–86.7) | 77.8 (52.4–93.6) | 75.0 (54.4–88.3) | 70.0 (53.7–82.4) | 0.92 |
| White matter in temporal lobe | 0.80 (0.63–0.91) | 100.0 (81.5–100.0) | 50.0 (26.0–74.0) | 66.7 (55.8–76.0) | 100.0 | −0.53 |
| Gray matter in temporal lobe | 0.82 (0.66–0.93) | 88.9 (65.3–98.6) | 77.8 (52.4–93.6) | 80.0 (62.4–90.6) | 87.5 (64.9–96.4) | −0.26 |
| Pons | 0.70 (0.52–0.84) | 61.1 (35.7–82.7) | 88.9 (65.3–98.6) | 84.6 (58.6–95.5) | 69.6 (55.6–80.7) | 0.82 |
| White matter in occipital lobe | 0.82 (0.65–0.93) | 83.3 (58.6–96.4) | 72.2 (46.5–90.3) | 75.0 (58.1–86.7) | 81.2 (59.7–92.7) | −0.76 |
| Gray matter in occipital lobe | 0.88 (0.72–0.96) | 88.9 (65.3–98.6) | 72.2 (46.5–90.3) | 76.2 (59.9–87.3) | 86.7 (63.0–96.1) | −0.47 |
| White matter in frontal lobe | 0.78 (0.62–0.90) | 77.8 (52.4–93.6) | 77.8 (52.4–93.6) | 77.8 (58.8–89.6) | 77.8 (58.8–89.6) | −0.63 |
| Thalamus | 0.72 (0.54–0.85) | 77.8 (52.4–93.6) | 61.1 (35.7–82.7) | 66.7 (51.6–79.0) | 73.3 (51.8–87.6) | 0.75 |
| Putamen | 0.73 (0.56–0.86) | 50.0 (26.0–74.0) | 88.9 (65.3–98.6) | 81.8 (53.0–94.7) | 64.0 (52.1–74.4) | 0.61 |
APTw, amide proton transfer-weighted; aMCI, amnestic mild cognitive; AUC, area under the ROC (receiver operator characteristic) curve; CI, confidence interval; PPV, positive predictive value; NPV, negative predictive value.