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. 2020 Jan 2;13(2):410–422. doi: 10.1016/j.tranon.2019.10.010

Figure 1.

Figure 1

Homologous recombination repair pathway (adapted from De Picciotto et al.) [117]. Several proteins are involved, such as BRCA1 and BRCA2 that if mutated in the germline, are responsible for the hereditary breast and ovarian cancer syndrome (HBOCS). Almost 50% of triple-negative breast cancer (TNBC) harbors a mutation in the genes involved in HRR pathway. HRR = homologous recombination repair pathway