Fig 4. Conceptual summary of the role of prodromal cervical immune aberrance as predictor of dysbiosis and sexually transmitted infections based the evidence from our longitudinal analyses.

Immune mediators are featured based on odds ratios for top and bottom quartile concentrations at the visits preceding CVI diagnosis. The independent predictive value of BD-2 and SLPI for HIV seroconversion has been previously established (Morrison et al). Future research must address the determinants of prodromal innate immunity.