Table 1. Likelihood ratios (LR) estimating the value of top quartile biomarker concentrations to predict incident cervicovaginal infection (CVI) outcomes at the next quarterly visit.
A value of 1 indicates a random occurrence of an incident CVI, e.g. vaginal dysbiosis or sexually transmitted infection. Values ≠ 1 indicate non-random distribution and are highlighted if >1 (higher likelihood, orange) or <1 (lower likelihood, blue).
| Predicted Incident CVI Outcomes | |||||||
|---|---|---|---|---|---|---|---|
| Vaginal dysbiosis | Sexually Transmitted Infections | ||||||
| Predictive Biomarker: Top quartile levels at the visit prior to CVI incidence |
Nugent 4–6 (n = 445) |
BV (n = 477) |
Candida (n = 271) |
NG (n = 71) |
TV (n = 82) |
CT (n = 58) |
HSV-2 (n = 36 |
| IL-1β | 4.67a | 3.22 | 2.39 | 0.44 | 0.44 | 0.28 | 0.22 |
| BD-2 | 3.74 | 4.21 | 2.42 | 0.37 | 0.58 | 0.53 | 0.37 |
| RANTES | 2.95 | 3.09 | 2.45 | 0.64 | 0.27 | 0.36 | 0.27 |
| MIP-3α | 4.88 | 3.35 | 2.35 | 0.53 | 0.29 | 0.24 | 0.24 |
| IL-6 | 3.91 | 2.91 | 1.74 | 0.39 | 0.30 | 0.04b | 0.09 |
| IL-8 | 3.77 | 2.77 | 1.95 | 0.41 | 0.36 | 0.23 | 0.27 |
| SLPI | 3.00 | 2.03 | 1.55 | 0.34 | 0.28 | 0.14 | 0.10 |
| IL-1RA | 2.67 | 1.87 | 1.50 | 0.30 | 0.33 | 0.23 | 0.13 |
| ICAM-1 | 2.53 | 1.80 | 1.40 | 0.50 | 0.23 | 0.33 | 0.10 |
| VEGF | 3.18 | 2.00 | 1.21 | 0.25 | 0.29 | 0.25 | 0.25 |
| IL-1RA:IL-1β | 0.89 | 1.02 | 0.60 | 0.21 | 0.28 | 0.16 | 0.11 |
aValues of significantly higher chance/likelihood of incident CVI at the next visit (≥1.5 based on 2-sided z score test with a 0.05 significance level) are highlighted with darker shade and bolded.
bValues of significantly lower chance/likelihood of incident CVI at the next visit (≤0.11, p<0.05, 2-sided z -score) are highlighted in darker shade, bolded and italicized.